Family Guy didn’t predict shit.
Homophobia is directed at straight people too, to remind them to not be like us, and sometimes it hits a straight person who is actually not straight and just closeted. Transphobia is directed at cis people too, to remind them not to be like us. And so many trans people have early experiences while living as the gender they don’t identify, managing every little behavioral tick so that no one would guess that they were trans. Sometimes that’s for fear that everyone would actually believe it, and then the transphobia would never stop. Sometimes it’s just because even worse than transphobia is the transphobia you face before even getting to transition, the transphobia that teaches some of us to never transition. I know too many people who have chosen to never transition because of this.